Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | ALK tyrosine kinase receptor | ||
| Ligand | BDBM50157880 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1565866 (CHEMBL3789970) | ||
| IC50 | 760±n/a nM | ||
| Citation |  Fairhurst, RA; Marsilje, TH; Stutz, S; Boos, A; Niklaus, M; Chen, B; Jiang, S; Lu, W; Furet, P; McCarthy, C; Stauffer, F; Guagnano, V; Vaupel, A; Michellys, PY; Schnell, C; Jeay, S Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors. Bioorg Med Chem Lett26:2057-64 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| ALK tyrosine kinase receptor | |||
| Name: | ALK tyrosine kinase receptor | ||
| Synonyms: | ALK | ALK tyrosine kinase receptor (ALK) | ALK_HUMAN | Anaplastic lymphoma kinase | CD_antigen: CD246 | ||
| Type: | Protein | ||
| Mol. Mass.: | 176453.10 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9UM73 | ||
| Residue: | 1620 | ||
| Sequence: |
| ||
| BDBM50157880 | |||
| n/a | |||
| Name | BDBM50157880 | ||
| Synonyms: | CHEMBL3787112 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H23N5O | ||
| Mol. Mass. | 349.4295 | ||
| SMILES | Nc1ncnc2n(cc(-c3cccc(O)c3)c12)[C@@H]1C[C@H](CN2CCC2)C1 |r,wD:17.19,19.22,(-1.03,2.79,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.23,2.7,;3.76,2.91,;4.33,4.34,;3.38,5.56,;1.86,5.34,;1.1,6.31,;1.29,3.91,;.3,.77,;2.24,-2.7,;3.54,-3.45,;2.74,-4.76,;3.1,-6.25,;4.58,-6.69,;5.27,-8.02,;6.62,-7.28,;5.88,-5.93,;1.42,-3.96,)| | ||
| Structure | 
| ||