Reaction Details | |||
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Target | Insulin-like growth factor 1 receptor | ||
Ligand | BDBM50315887 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1570070 (CHEMBL3789672) | ||
IC50 | 14±n/a nM | ||
Citation | Fairhurst, RA; Marsilje, TH; Stutz, S; Boos, A; Niklaus, M; Chen, B; Jiang, S; Lu, W; Furet, P; McCarthy, C; Stauffer, F; Guagnano, V; Vaupel, A; Michellys, PY; Schnell, C; Jeay, S Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors. Bioorg Med Chem Lett26:2057-64 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Insulin-like growth factor 1 receptor | |||
Name: | Insulin-like growth factor 1 receptor | ||
Synonyms: | CD_antigen=CD221 | IGF-I receptor | IGF1R | IGF1R_HUMAN | Insulin-like growth factor 1 receptor (IGF1R) | Insulin-like growth factor 1 receptor (IGFIR) | Insulin-like growth factor 1 receptor alpha chain | Insulin-like growth factor 1 receptor beta chain | Insulin-like growth factor I receptor | Insulin-like growth factor receptor (IGFR) | ||
Type: | Protein | ||
Mol. Mass.: | 154776.79 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08069 | ||
Residue: | 1367 | ||
Sequence: |
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BDBM50315887 | |||
n/a | |||
Name | BDBM50315887 | ||
Synonyms: | (1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol | CHEMBL1091644 | OSI-906 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H23N5O | ||
Mol. Mass. | 421.4937 | ||
SMILES | C[C@@]1(O)C[C@@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12 |r,wU:1.1,4.6,wD:1.0,(18.42,-37.26,;17.1,-36.49,;16.31,-37.82,;17.79,-35.11,;16.41,-34.42,;15.72,-35.8,;15.93,-32.97,;16.83,-31.71,;15.91,-30.47,;16.38,-29.01,;15.35,-27.88,;15.81,-26.41,;17.32,-26.08,;17.78,-24.62,;19.27,-24.29,;20.31,-25.42,;19.85,-26.89,;18.35,-27.21,;17.89,-28.68,;21.81,-25.09,;22.85,-26.23,;24.35,-25.9,;24.82,-24.43,;23.77,-23.29,;22.27,-23.63,;14.45,-30.96,;13.11,-30.19,;13.11,-28.65,;11.78,-30.96,;11.78,-32.51,;13.12,-33.28,;14.46,-32.5,)| | ||
Structure |