Reaction Details | |||
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Target | Insulin-like growth factor 1 receptor | ||
Ligand | BDBM50158428 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1570070 (CHEMBL3789672) | ||
IC50 | 33±n/a nM | ||
Citation | Fairhurst, RA; Marsilje, TH; Stutz, S; Boos, A; Niklaus, M; Chen, B; Jiang, S; Lu, W; Furet, P; McCarthy, C; Stauffer, F; Guagnano, V; Vaupel, A; Michellys, PY; Schnell, C; Jeay, S Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors. Bioorg Med Chem Lett26:2057-64 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Insulin-like growth factor 1 receptor | |||
Name: | Insulin-like growth factor 1 receptor | ||
Synonyms: | CD_antigen=CD221 | IGF-I receptor | IGF1R | IGF1R_HUMAN | Insulin-like growth factor 1 receptor (IGF1R) | Insulin-like growth factor 1 receptor (IGFIR) | Insulin-like growth factor 1 receptor alpha chain | Insulin-like growth factor 1 receptor beta chain | Insulin-like growth factor I receptor | Insulin-like growth factor receptor (IGFR) | ||
Type: | Protein | ||
Mol. Mass.: | 154776.79 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08069 | ||
Residue: | 1367 | ||
Sequence: |
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BDBM50158428 | |||
n/a | |||
Name | BDBM50158428 | ||
Synonyms: | CHEMBL3787567 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H28N4O3 | ||
Mol. Mass. | 420.5041 | ||
SMILES | Nc1ncnc2n(cc(-c3cccc(OCC45CCC(CC4)O5)c3)c12)[C@@H]1C[C@H](CO)C1 |r,wD:25.29,27.32,(-1.03,2.79,;-1.03,1.56,;-2.38,.77,;-2.38,-.77,;-1.03,-1.56,;.3,-.77,;1.77,-1.24,;2.67,.02,;1.77,1.24,;2.24,2.71,;3.77,2.92,;4.35,4.36,;3.4,5.57,;1.87,5.35,;.91,6.57,;1.49,8.01,;.54,9.22,;-.78,8.63,;-1.88,9.69,;-1.51,11.18,;-.02,11.58,;1.07,10.52,;-.08,10.37,;1.29,3.92,;.3,.77,;2.25,-2.71,;3.55,-3.46,;2.75,-4.78,;3.11,-6.27,;4.29,-6.62,;1.43,-3.97,)| | ||
Structure |