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TargetChromobox protein homolog 8
LigandBDBM50155931
Substrate/Competitorn/a
Meas. Tech.ChEBML_1565747
Kd 1000±n/a nM
Citation Milosevich NGignac MCMcFarlane JSimhadri CHorvath SDaze KDCroft CSDheri AQuon TTDouglas SFWulff JEPaci IHof F Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family. ACS Med Chem Lett 7:139-44 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Chromobox protein homolog 8
Name:Chromobox protein homolog 8
Synonyms:CBX8 | PC3 | Pc3 | Polycomb 3 homolog | RC1 | Rectachrome 1 | hPc3
Type:PROTEIN
Mol. Mass.:43415.86
Organism:Homo sapiens (Human)
Description:ChEMBL_108272
Residue:389
Sequence:
MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEER
EREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSARGIRIPYPGRSPQDLASTSRA
REGLRNMGLSPPASSTSTSSTCRAEAPRDRDRDRDRDRERDRERERERERERERERERER
GTSRVDDKPSSPGDSSKKRGPKPRKELPDPSQRPLGEPSAGLGEYLKGRKLDDTPSGAGK
FPAGHSVIQLARRQDSDLVQCGVTSPSSAEATGKLAVDTFPARVIKHRAAFLEAKGQGAL
DPNGTRVRHGSGPPSSGGGLYRDMGAQGGRPSLIARIPVARILGDPEEESWSPSLTNLEK
VVVTDVTSNFLTVTIKESNTDQGFFKEKR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50155931
n/a
NameBDBM50155931
Synonyms:CHEMBL3780251
TypeSmall organic molecule
Emp. Form.C72H83BrN11O17S
Mol. Mass.1486.461
SMILESC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O |r,wU:5.5,26.28,50.53,wD:1.0,38.41,56.59,65.68,(13.64,33.73,;14.71,33.11,;16.05,33.88,;16.05,35.42,;14.98,36.04,;17.38,36.19,;18.71,35.42,;18.71,33.88,;20.04,33.1,;20.03,31.56,;18.7,30.8,;17.37,31.57,;17.37,33.11,;17.38,37.73,;18.72,38.5,;19.79,37.89,;18.72,40.04,;20.05,40.82,;20.05,42.36,;18.72,43.12,;18.72,44.36,;17.39,42.35,;17.39,40.81,;14.71,31.57,;15.77,30.96,;13.37,30.8,;13.37,29.26,;14.7,28.49,;14.7,26.95,;16.03,26.17,;16.02,24.63,;14.69,23.87,;14.68,22.64,;13.36,24.64,;13.36,26.18,;12.04,28.49,;10.97,29.11,;12.03,26.95,;10.7,26.18,;9.36,26.95,;8.03,26.18,;6.7,26.95,;5.36,26.18,;4.03,26.95,;2.96,26.33,;2.96,27.56,;4.03,28.18,;10.7,24.64,;11.76,24.03,;9.36,23.87,;9.36,22.33,;10.69,21.56,;10.69,20.33,;8.03,21.56,;6.96,22.18,;8.02,20.02,;6.69,19.25,;5.35,20.02,;4.02,19.25,;2.68,20.02,;2.68,21.25,;1.62,19.4,;6.69,17.71,;7.75,17.09,;5.35,16.94,;5.35,15.4,;4.02,14.63,;4.01,13.09,;2.68,12.32,;2.68,10.78,;1.34,10.01,;1.34,8.47,;2.41,7.85,;0,7.7,;0,6.16,;-1.33,5.39,;-1.33,3.85,;0,3.08,;1.34,3.85,;1.34,5.39,;2.67,3.09,;2.68,2.06,;3.74,3.7,;,1.54,;-1.33,.77,;-2.67,1.54,;-4,.77,;-4,-.77,;-5.07,-1.39,;-2.67,-1.54,;-1.33,-.77,;,-1.54,;1.31,-.77,;2.67,-1.54,;4,-.77,;5.07,-1.39,;4,.77,;2.67,1.54,;1.31,.77,;6.68,14.63,;7.75,15.24,;6.68,13.4,)|
Structure
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