| Reaction Details |
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 | Report a problem with these data |
| Target | Chromobox protein homolog 6 |
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| Ligand | BDBM50157400 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1565748 (CHEMBL3782546) |
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| Kd | 910±n/a nM |
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| Citation |  Milosevich, N; Gignac, MC; McFarlane, J; Simhadri, C; Horvath, S; Daze, KD; Croft, CS; Dheri, A; Quon, TT; Douglas, SF; Wulff, JE; Paci, I; Hof, F Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family. ACS Med Chem Lett7:139-44 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chromobox protein homolog 6 |
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| Name: | Chromobox protein homolog 6 |
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| Synonyms: | CBX6 | CBX6_HUMAN | Chromobox protein homolog 6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43924.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116765 |
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| Residue: | 412 |
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| Sequence: | MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQK
ERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLK
KDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKV
IDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHMKFGAFALYKPPPA
PLVAPSPGKAEASAPGPGLLLAAPAAPYDARSSGSSGCPSPTPQSSDPDDTPPKLLPETV
SPSAPSWREPEVLDLSLPPESAATSKRAPPEVTAAAGPAPPTAPEPAGASSEPEAGDWRP
EMSPCSNVVVTDVTSNLLTVTIKEFCNPEDFEKVAAGVAGAAGGGGSIGASK
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| BDBM50157400 |
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| n/a |
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| Name | BDBM50157400 |
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| Synonyms: | CHEMBL3781600 |
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| Type | Small organic molecule |
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| Emp. Form. | C63H90BrN12O14S |
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| Mol. Mass. | 1351.429 |
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| SMILES | [H][C@]12CS[C@@H](CCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCC[N+](C)(C)C)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)c3ccc(Br)cc3)C(C)C)C(N)=O)[C@@]1([H])NC(=O)N2 |r| |
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| Structure | 
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