Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetChromobox protein homolog 6
LigandBDBM50157400
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1565748
Kd 910±n/a nM
Citation Milosevich NGignac MCMcFarlane JSimhadri CHorvath SDaze KDCroft CSDheri AQuon TTDouglas SFWulff JEPaci IHof F Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family. ACS Med Chem Lett 7:139-44 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Chromobox protein homolog 6
Name:Chromobox protein homolog 6
Synonyms:CBX6 | Chromobox protein homolog 6
Type:PROTEIN
Mol. Mass.:43924.51
Organism:Homo sapiens (Human)
Description:ChEMBL_116765
Residue:412
Sequence:
MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQK
ERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLK
KDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKV
IDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHMKFGAFALYKPPPA
PLVAPSPGKAEASAPGPGLLLAAPAAPYDARSSGSSGCPSPTPQSSDPDDTPPKLLPETV
SPSAPSWREPEVLDLSLPPESAATSKRAPPEVTAAAGPAPPTAPEPAGASSEPEAGDWRP
EMSPCSNVVVTDVTSNLLTVTIKEFCNPEDFEKVAAGVAGAAGGGGSIGASK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50157400
n/a
NameBDBM50157400
Synonyms:CHEMBL3781600
TypeSmall organic molecule
Emp. Form.C63H90BrN12O14S
Mol. Mass.1351.429
SMILES[H][C@]12CS[C@@H](CCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCC[N+](C)(C)C)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)c3ccc(Br)cc3)C(C)C)C(N)=O)[C@@]1([H])NC(=O)N2 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: