Reaction Details | |||
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Target | Bromodomain-containing protein 4 | ||
Ligand | BDBM50156118 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1569661 (CHEMBL3791134) | ||
IC50 | <14±n/a nM | ||
Citation | Romero, FA; Taylor, AM; Crawford, TD; Tsui, V; Côté, A; Magnuson, S Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors. J Med Chem59:1271-98 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Bromodomain-containing protein 4 | |||
Name: | Bromodomain-containing protein 4 | ||
Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | HUNK1 | Protein HUNK1 | ||
Type: | Protein | ||
Mol. Mass.: | 152264.84 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60885 | ||
Residue: | 1362 | ||
Sequence: |
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BDBM50156118 | |||
n/a | |||
Name | BDBM50156118 | ||
Synonyms: | CHEMBL3785327 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H18N4O2 | ||
Mol. Mass. | 370.4039 | ||
SMILES | Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2[nH]c(=O)[nH]c2c1 |(2.99,-4.33,;2.74,-5.54,;3.77,-6.69,;3,-8.03,;1.49,-7.71,;.57,-8.53,;1.35,-6.18,;.01,-5.41,;.02,-3.87,;-1.33,-3.08,;-1.33,-1.54,;-2.69,-.77,;-3.75,-1.39,;-2.69,.77,;-1.33,1.54,;,.77,;1.33,1.54,;2.67,.77,;2.67,-.77,;1.33,-1.54,;,-.77,;-2.66,-3.87,;-4.12,-3.39,;-5.03,-4.65,;-6.26,-4.65,;-4.13,-5.87,;-2.67,-5.4,;-1.34,-6.19,)| | ||
Structure |