Reaction Details |
| Report a problem with these data |
Target | Dihydrofolate reductase |
---|
Ligand | BDBM50157638 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_1567918 |
---|
Ki | 5.8±n/a nM |
---|
Citation | Kaur, J; Kaur, S; Singh, P Rational modification of the lead molecule: Enhancement in the anticancer and dihydrofolate reductase inhibitory activity. Bioorg Med Chem Lett26:1936-40 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dihydrofolate reductase |
---|
Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
BDBM50157638 |
---|
n/a |
---|
Name | BDBM50157638 |
Synonyms: | CHEMBL3787137 |
Type | Small organic molecule |
Emp. Form. | C37H28N4O3 |
Mol. Mass. | 576.6432 |
SMILES | OC(Cn1cc(\C=C2/C(=O)Nc3ccccc23)c2ccccc12)Cn1cc(\C=C2/C(=O)Nc3ccccc23)c2ccccc12 |
Structure |
|