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Reaction Details
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TargetSynaptic vesicular amine transporter
LigandBDBM50433783
Substrate/Competitorn/a
Meas. Tech.ChEBML_1571954
Ki 29±n/a nM
Citation Joolakanti, SRNickell, JRJanganati, VZheng, GDwoskin, LPCrooks, PA Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg Med Chem Lett26:2422-7 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Synaptic vesicular amine transporter
Name:Synaptic vesicular amine transporter
Synonyms:Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2
Type:Protein
Mol. Mass.:55689.58
Organism:Rattus norvegicus (Rat)
Description:Q01827
Residue:515
Sequence:
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
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  Blast E-value cutoff:
BDBM50433783
n/a
NameBDBM50433783
Synonyms:CHEMBL2381721
TypeSmall organic molecule
Emp. Form.C26H37NO4
Mol. Mass.427.5763
SMILESCOc1ccc(CC[C@H]2CCC[C@@H](CCc3ccc(OC)cc3)N2C[C@@H](O)CO)cc1 |r|
Structure
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