Reaction Details |
| Report a problem with these data |
Target | Serine protease hepsin |
---|
Ligand | BDBM50158162 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1565753 (CHEMBL3782551) |
---|
Ki | 61200±n/a nM |
---|
Citation | Venukadasula, PK; Owusu, BY; Bansal, N; Ross, LJ; Hobrath, JV; Bao, D; Truss, JW; Stackhouse, M; Messick, TE; Klampfer, L; Galemmo, RA Design and Synthesis of Nonpeptide Inhibitors of Hepatocyte Growth Factor Activation. ACS Med Chem Lett7:177-81 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine protease hepsin |
---|
Name: | Serine protease hepsin |
Synonyms: | HEPS_HUMAN | HPN | Hepsin | Serine protease hepsin | TMPRSS1 | Transmembrane protease serine 11E | Transmembrane protease, serine 1 |
Type: | Enzyme |
Mol. Mass.: | 45016.98 |
Organism: | Homo sapiens (Human) |
Description: | Human deglycosylated hepsin was expressed in Pichia pastoris. |
Residue: | 417 |
Sequence: | MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
|
|
|
BDBM50158162 |
---|
n/a |
---|
Name | BDBM50158162 |
Synonyms: | CHEMBL3780437 |
Type | Small organic molecule |
Emp. Form. | C24H31N5O |
Mol. Mass. | 405.5358 |
SMILES | CC1CN(C2CCN(Cc3ccccc3)CC2)C(=O)N(C1)c1ccc(cc1)C(N)=N |
Structure |
|