| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease hepsin |
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| Ligand | BDBM50158158 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1565753 (CHEMBL3782551) |
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| Ki | 760±n/a nM |
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| Citation |  Venukadasula, PK; Owusu, BY; Bansal, N; Ross, LJ; Hobrath, JV; Bao, D; Truss, JW; Stackhouse, M; Messick, TE; Klampfer, L; Galemmo, RA Design and Synthesis of Nonpeptide Inhibitors of Hepatocyte Growth Factor Activation. ACS Med Chem Lett7:177-81 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease hepsin |
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| Name: | Serine protease hepsin |
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| Synonyms: | HEPS_HUMAN | HPN | Hepsin | Serine protease hepsin | TMPRSS1 | Transmembrane protease serine 11E | Transmembrane protease, serine 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 45016.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human deglycosylated hepsin was expressed in Pichia pastoris. |
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| Residue: | 417 |
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| Sequence: | MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
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| BDBM50158158 |
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| n/a |
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| Name | BDBM50158158 |
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| Synonyms: | CHEMBL3780208 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H37N5O2 |
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| Mol. Mass. | 511.6578 |
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| SMILES | NC(=N)c1cccc(c1)N1CC(CN(CC2CCN(Cc3ccccc3)CC2)C1=O)OCc1ccccc1 |
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| Structure | 
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