Reaction Details |
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Target | Transient receptor potential cation channel subfamily A member 1 |
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Ligand | BDBM50157631 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1569237 (CHEMBL3791661) |
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IC50 | 10.0±n/a nM |
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Citation | Schenkel, LB; Olivieri, PR; Boezio, AA; Deak, HL; Emkey, R; Graceffa, RF; Gunaydin, H; Guzman-Perez, A; Lee, JH; Teffera, Y; Wang, W; Youngblood, BD; Yu, VL; Zhang, M; Gavva, NR; Lehto, SG; Geuns-Meyer, S Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity. J Med Chem59:2794-809 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transient receptor potential cation channel subfamily A member 1 |
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Name: | Transient receptor potential cation channel subfamily A member 1 |
Synonyms: | Anktm1 | TRPA1_RAT | Trpa1 |
Type: | PROTEIN |
Mol. Mass.: | 128622.74 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1450487 |
Residue: | 1125 |
Sequence: | MKRSLRRVLRPEERKEVQGVVYRGVGKDMDCSKESFKVDIEGDMCRLEAFIKNRRKLSKY
EDENLCLLHHAAAEGQVELMQLIINGSSCEALNVMDDYGNTPLHWAAEKNQVESVKFLLS
QGANPNLRNRNMMAPLHIAVQGMYNEVIKVLTEHKATNINLEGENGNTALMSTCAKDNSE
ALQILLEKGAKLCKSNKWGDYPVHQAAFSGAKRCMELILAYGEKTGYSREAHINFVNHKK
ASPLHLAVQSGDLDMIKMCLDSGAHIDMMENAKCMALHFAATQGATDIVKLMISSYTGSS
DIVNAVDGNQETLLHRASLFDHHDLADYLISVGADINSTDSEGRSPLILATASASWNIVN
LLLSKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPEFLQMQHIKELVMDEDNDGCTPLHY
ACRQGAPVSVNNLLRFNVSVHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD
LHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLK
CTDRLDEEGNTALHFAAREGHAKAVAMLLSYNADILLNKKQASFLHIALHNKRKEVVLTT
IRSKRWDECLQVFTHDSPSNRCPIMEMVEYLPECMKVLLDFCMIPSTEDKSCQDYHIEYN
FKYLQCPLSMTKKVTPTQDVIYEPLTILNVMVQHNRIELLNHPVCREYLLMKWCAYGFRA
HMMNLGSYCLGLIPMTLLVVKIQPGMAFNSTGIINETISTHEERINTLNSFPLKICMILV
FLSSIFGYCKEVVQIFQQKRNYFLDYNNALEWVIYTTSMIFVLPLFLDIPAYMQWQCGAI
AIFFYWMNFLLYLQRFENCGIFIVMLEVIFKTLLRSTGVFIFLLLAFGLSFYVLLNFQDA
FSTPLLSLIQTFSMMLGDINYRDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLI
GLAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPFWYLRKVDQRSTIVYPNRPRHGRMLR
FFHYFLSMQETRQEAPNIDTCLEMEILKQKYRLKDLTSLLEKQHELIKLIIQKMEIISET
EDEDNHCSFQDRFKKERLEQMHSKWNFVLNAVKTKTHCSISHPDI
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BDBM50157631 |
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n/a |
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Name | BDBM50157631 |
Synonyms: | CHEMBL3785736 |
Type | Small organic molecule |
Emp. Form. | C17H15ClN6O2 |
Mol. Mass. | 370.793 |
SMILES | Cn1cnc2ncn(Cc3nc(CCc4ccc(Cl)cc4)no3)c(=O)c12 |
Structure |
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