| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50157866 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1569753 (CHEMBL3791697) |
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| Ki | 16±n/a nM |
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| Citation |  Lan, Y; Songyang, Y; Zhang, L; Peng, Y; Song, J Synthesis and biological evaluation of novel 6,7-dihydro-5H-cyclopenta[d]pyrimidine and 5,6,7,8-tetrahydroquinazoline derivatives as sigma-1 (s1) receptor antagonists for the treatment of pain. Bioorg Med Chem Lett26:2051-6 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
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| Type: | Protein |
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| Mol. Mass.: | 25307.17 |
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| Organism: | Cavia porcellus (Guinea pig) |
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| Description: | Q60492 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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| BDBM50157866 |
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| n/a |
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| Name | BDBM50157866 |
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| Synonyms: | CHEMBL3785238 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30ClN3O |
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| Mol. Mass. | 399.957 |
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| SMILES | CC1CCN(CCCOc2nc(nc3CCCCc23)-c2ccc(Cl)cc2)CC1 |
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| Structure | 
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