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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Proto-oncogene tyrosine-protein kinase receptor Ret | ||
| Ligand | BDBM50157881 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1570040 (CHEMBL3789403) | ||
| IC50 | 4400±n/a nM | ||
| Citation |  Stauffer, F; Cowan-Jacob, SW; Scheufler, C; Furet, P Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors. Bioorg Med Chem Lett26:2065-7 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Proto-oncogene tyrosine-protein kinase receptor Ret | |||
| Name: | Proto-oncogene tyrosine-protein kinase receptor Ret | ||
| Synonyms: | CDHF12 | CDHR16 | Cadherin family member 12 | PTC | Proto-oncogene c-Ret | RET | RET51 | RET_HUMAN | Tyrosine-protein kinase Ret (RET) | ||
| Type: | Protein | ||
| Mol. Mass.: | 124318.29 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P07949 | ||
| Residue: | 1114 | ||
| Sequence: |
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| BDBM50157881 | |||
| n/a | |||
| Name | BDBM50157881 | ||
| Synonyms: | CHEMBL3787614 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H31N5O2 | ||
| Mol. Mass. | 433.5459 | ||
| SMILES | Nc1ncnc2n(cc(-c3cccc(OC[C@@H]4CCCO4)c3)c12)[C@@H]1C[C@H](CN2CCC2)C1 |r,wD:23.26,16.15,25.29,(-1.03,2.79,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.23,2.7,;3.76,2.91,;4.33,4.34,;3.38,5.55,;1.86,5.34,;.91,6.55,;1.49,7.98,;.54,9.2,;-.98,9.12,;-1.51,10.57,;-.3,11.52,;.98,10.66,;1.29,3.91,;.3,.77,;2.24,-2.7,;3.54,-3.45,;2.74,-4.76,;3.1,-6.25,;4.58,-6.69,;5.27,-8.02,;6.62,-7.28,;5.88,-5.93,;1.42,-3.96,)| | ||
| Structure | 
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