| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-alpha |
|---|
| Ligand | BDBM50157942 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1564170 (CHEMBL3784067) |
|---|
| EC50 | 6.3±n/a nM |
|---|
| Citation |  Sundén, H; Schäfer, A; Scheepstra, M; Leysen, S; Malo, M; Ma, JN; Burstein, ES; Ottmann, C; Brunsveld, L; Olsson, R Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation. J Med Chem59:1232-8 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Retinoic acid receptor RXR-alpha |
|---|
| Name: | Retinoic acid receptor RXR-alpha |
|---|
| Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50820.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1456363 |
|---|
| Residue: | 462 |
|---|
| Sequence: | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
|
|
|
|---|
| BDBM50157942 |
|---|
| n/a |
|---|
| Name | BDBM50157942 |
|---|
| Synonyms: | CHEMBL3781132 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H30O3 |
|---|
| Mol. Mass. | 390.5146 |
|---|
| SMILES | [H][C@@]12CCC[C@@]1(c1cc3c(cc1O2)C(C)(C)CCC3(C)C)c1ccc(cc1)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
