| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 8 |
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| Ligand | BDBM50158094 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1564311 (CHEMBL3784632) |
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| IC50 | 2100±n/a nM |
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| Citation |  Ferreira de Freitas, R; Eram, MS; Szewczyk, MM; Steuber, H; Smil, D; Wu, H; Li, F; Senisterra, G; Dong, A; Brown, PJ; Hitchcock, M; Moosmayer, D; Stegmann, CM; Egner, U; Arrowsmith, C; Barsyte-Lovejoy, D; Vedadi, M; Schapira, M Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. J Med Chem59:1176-83 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 8 |
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| Name: | Protein arginine N-methyltransferase 8 |
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| Synonyms: | ANM8_HUMAN | HRMT1L3 | HRMT1L3 | HRMT1L4 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 | PRMT8 | Protein arginine N-methyltransferase 8 | Protein arginine N-methyltransferase 8 (PRMT8) | Protein arginine methyltransferase 8 (PRMT8) |
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| Type: | Protein |
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| Mol. Mass.: | 45293.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 394 |
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| Sequence: | MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGK
MSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGS
GTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVD
IIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWE
NVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQR
NDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISM
KPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR
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| BDBM50158094 |
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| n/a |
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| Name | BDBM50158094 |
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| Synonyms: | CHEMBL3780926 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H22N2 |
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| Mol. Mass. | 218.3379 |
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| SMILES | NCCN1CCC(Cc2ccccc2)CC1 |
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| Structure | 
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