| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 4E |
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| Ligand | BDBM50158849 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1565784 (CHEMBL3789169) |
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| IC50 | 5000±n/a nM |
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| Citation |  McAllister, TE; England, KS; Hopkinson, RJ; Brennan, PE; Kawamura, A; Schofield, CJ Recent Progress in Histone Demethylase Inhibitors. J Med Chem59:1308-29 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 4E |
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| Name: | Lysine-specific demethylase 4E |
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| Synonyms: | 2-OG-Dependent Histone Demethylase JMJD2E | Histone Lysine Demethylase | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | KDM4DL | KDM4E | KDM4E_HUMAN | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56815.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | B2RXH2 |
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| Residue: | 506 |
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| Sequence: | MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMY
DDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQ
RYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLR
HKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDY
GKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRD
DIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT
LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLL
MGTRSRAQGHRPQLPLANDLMTNLSL
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| BDBM50158849 |
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| n/a |
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| Name | BDBM50158849 |
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| Synonyms: | CHEMBL3785164 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17ClN2O2S |
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| Mol. Mass. | 408.901 |
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| SMILES | Cc1ccsc1C(NC(=O)c1ccccc1)c1cc(Cl)c2cccnc2c1O |
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| Structure | 
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