| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific histone demethylase 1A |
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| Ligand | BDBM50158872 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1565790 (CHEMBL3789175) |
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| IC50 | 6.0±n/a nM |
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| Citation |  McAllister, TE; England, KS; Hopkinson, RJ; Brennan, PE; Kawamura, A; Schofield, CJ Recent Progress in Histone Demethylase Inhibitors. J Med Chem59:1308-29 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific histone demethylase 1A |
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| Name: | Lysine-specific histone demethylase 1A |
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| Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 92901.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60341 |
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| Residue: | 852 |
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| Sequence: | MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
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| BDBM50158872 |
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| n/a |
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| Name | BDBM50158872 |
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| Synonyms: | CHEMBL3785523 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H24N2 |
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| Mol. Mass. | 244.3752 |
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| SMILES | CN1CCC(CN[C@@H]2C[C@H]2c2ccccc2)CC1 |r| |
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| Structure | 
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