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TargetMelanin-concentrating hormone receptor 1
LigandBDBM50159144
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1566584 (CHEMBL3791478)
IC50 9±n/a nM
Citation Johansson, ALöfberg, CAntonsson, Mvon Unge, SHayes, MAJudkins, RPloj, KBenthem, LLindén, DBrodin, PWennerberg, MFredenwall, MLi, LPersson, JBergman, RPettersen, AGennemark, PHogner, A Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties. J Med Chem59:2497-511 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanin-concentrating hormone receptor 1
Name:Melanin-concentrating hormone receptor 1
Synonyms:Gpr24 | MCHR1_MOUSE | Mchr1 | Slc1
Type:PROTEIN
Mol. Mass.:39133.74
Organism:Mus musculus
Description:ChEMBL_818502
Residue:353
Sequence:
MDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNST
VIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLIT
AMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWL
YARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVA
PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLG
YANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
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  Blast E-value cutoff:
BDBM50159144
n/a
NameBDBM50159144
Synonyms:CHEMBL3787261
TypeSmall organic molecule
Emp. Form.C25H28N4O5
Mol. Mass.464.5136
SMILESCOc1ccc(cc1)-c1nnc(o1)C(=O)N1CC(C1)Oc1ccc(CN2CCC(C)(O)C2)cc1
Structure
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