| Reaction Details |
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 | Report a problem with these data |
| Target | Excitatory amino acid transporter 1 |
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| Ligand | BDBM50159150 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1568619 (CHEMBL3791052) |
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| IC50 | >300000±n/a nM |
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| Citation |  Huynh, TH; Erichsen, MN; Tora, AS; Goudet, C; Sagot, E; Assaf, Z; Thomsen, C; Brodbeck, R; Stensbøl, TB; Bjørn-Yoshimoto, WE; Nielsen, B; Pin, JP; Gefflaut, T; Bunch, L New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. J Med Chem59:914-24 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Excitatory amino acid transporter 1 |
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| Name: | Excitatory amino acid transporter 1 |
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| Synonyms: | EAA1_HUMAN | EAAT1 | Excitatory Amino Acid EAAT1 | GLAST | GLAST1 | SLC1A3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59577.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Excitatory Amino Acid EAAT1 0 HUMAN::P43003 |
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| Residue: | 542 |
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| Sequence: | MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPP
NLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGK
IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSET
KM
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| BDBM50159150 |
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| n/a |
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| Name | BDBM50159150 |
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| Synonyms: | CHEMBL3787264 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H11NO6 |
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| Mol. Mass. | 217.176 |
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| SMILES | [H][C@@]1(C[C@]1(C[C@H](N)C(O)=O)C(O)=O)C(O)=O |r| |
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| Structure | 
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