| Reaction Details |
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 | Report a problem with these data |
| Target | Excitatory amino acid transporter 2 |
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| Ligand | BDBM50252049 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1568621 (CHEMBL3791054) |
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| IC50 | >300000±n/a nM |
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| Citation |  Huynh, TH; Erichsen, MN; Tora, AS; Goudet, C; Sagot, E; Assaf, Z; Thomsen, C; Brodbeck, R; Stensbøl, TB; Bjørn-Yoshimoto, WE; Nielsen, B; Pin, JP; Gefflaut, T; Bunch, L New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. J Med Chem59:914-24 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Excitatory amino acid transporter 2 |
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| Name: | Excitatory amino acid transporter 2 |
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| Synonyms: | EAA2_HUMAN | EAAT2 | GLT1 | Glutamate/aspartate transporter II | SLC1A2 | Sodium-dependent glutamate/aspartate transporter 2 | Solute carrier family 1 member 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 62103.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Excitatory Amino Acid EAAT2 0 0::P43004 |
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| Residue: | 574 |
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| Sequence: | MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC
GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA
MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL
VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM
NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI
IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG
TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL
DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS
VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA
AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
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| BDBM50252049 |
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| n/a |
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| Name | BDBM50252049 |
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| Synonyms: | (1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | (2S,4R)-4-(3-Hydroxy-3-oxopropyl)glutamic Acid | CHEMBL482081 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H13NO6 |
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| Mol. Mass. | 219.1919 |
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| SMILES | N[C@@H](C[C@@H](CCC(O)=O)C(O)=O)C(O)=O |r| |
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| Structure | 
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