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TargetReceptor-interacting serine/threonine-protein kinase 1
LigandBDBM50159700
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1569451 (CHEMBL3789113)
IC50 35±n/a nM
Citation Harris, PAKing, BWBandyopadhyay, DBerger, SBCampobasso, NCapriotti, CACox, JADare, LDong, XFinger, JNGrady, LCHoffman, SJJeong, JUKang, JKasparcova, VLakdawala, ASLehr, RMcNulty, DENagilla, ROuellette, MTPao, CSRendina, ARSchaeffer, MCSummerfield, JDSwift, BATotoritis, RDWard, PZhang, AZhang, DMarquis, RWBertin, JGough, PJ DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. J Med Chem59:2163-78 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Receptor-interacting serine/threonine-protein kinase 1
Name:Receptor-interacting serine/threonine-protein kinase 1
Synonyms:Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:Enzyme Catalytic Domain
Mol. Mass.:75926.99
Organism:Homo sapiens (Human)
Description:Q13546
Residue:671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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  Blast E-value cutoff:
BDBM50159700
n/a
NameBDBM50159700
Synonyms:CHEMBL3786660
TypeSmall organic molecule
Emp. Form.C23H19F3N6O3
Mol. Mass.484.4306
SMILESCN1c2ccccc2OC[C@H](NC(=O)c2cc(Cc3cccc(c3)C3(N=N3)C(F)(F)F)[nH]n2)C1=O |r,c:27|
Structure
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