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TargetReceptor-interacting serine/threonine-protein kinase 1
LigandBDBM50159507
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1569449
Ki 0.800000±n/a nM
Citation Harris PAKing BWBandyopadhyay DBerger SBCampobasso NCapriotti CACox JADare LDong XFinger JNGrady LCHoffman SJJeong JUKang JKasparcova VLakdawala ASLehr RMcNulty DENagilla ROuellette MTPao CSRendina ARSchaeffer MCSummerfield JDSwift BATotoritis RDWard PZhang AZhang DMarquis RWBertin JGough PJ DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. J Med Chem 59:2163-78 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Receptor-interacting serine/threonine-protein kinase 1
Name:Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1
Synonyms:RIP-1 | RIPK1 | Receptor-interacting protein 1
Type:Protein
Mol. Mass.:75926.99
Organism:Homo sapiens (Human)
Description:Q13546
Residue:671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50159507
n/a
NameBDBM50159507
Synonyms:CHEMBL3785703
TypeSmall organic molecule
Emp. Form.C21H19N3O4
Mol. Mass.377.3933
SMILESCN1c2ccccc2OC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O |r|
Structure
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