Reaction Details |
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Target | Monoglyceride lipase |
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Ligand | BDBM50160280 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1566097 (CHEMBL3791725) |
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IC50 | 13±n/a nM |
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Citation | Brindisi, M; Maramai, S; Gemma, S; Brogi, S; Grillo, A; Di Cesare Mannelli, L; Gabellieri, E; Lamponi, S; Saponara, S; Gorelli, B; Tedesco, D; Bonfiglio, T; Landry, C; Jung, KM; Armirotti, A; Luongo, L; Ligresti, A; Piscitelli, F; Bertucci, C; Dehouck, MP; Campiani, G; Maione, S; Ghelardini, C; Pittaluga, A; Piomelli, D; Di Marzo, V; Butini, S Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem59:2612-32 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Monoglyceride lipase |
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Name: | Monoglyceride lipase |
Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
Type: | Hydrolase |
Mol. Mass.: | 33264.56 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
Residue: | 303 |
Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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BDBM50160280 |
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n/a |
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Name | BDBM50160280 |
Synonyms: | CHEMBL3787340 |
Type | Small organic molecule |
Emp. Form. | C25H25N5O5 |
Mol. Mass. | 475.4965 |
SMILES | COc1ccc(cc1)[C@@H]1[C@H](N(C2CCN(CC2)C(=O)n2cncn2)C1=O)c1ccc2OCOc2c1 |r| |
Structure |
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