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TargetMonoglyceride lipase
LigandBDBM50160280
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1566097 (CHEMBL3791725)
IC50 13±n/a nM
Citation Brindisi, MMaramai, SGemma, SBrogi, SGrillo, ADi Cesare Mannelli, LGabellieri, ELamponi, SSaponara, SGorelli, BTedesco, DBonfiglio, TLandry, CJung, KMArmirotti, ALuongo, LLigresti, APiscitelli, FBertucci, CDehouck, MPCampiani, GMaione, SGhelardini, CPittaluga, APiomelli, DDi Marzo, VButini, S Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem59:2612-32 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Monoglyceride lipase
Name:Monoglyceride lipase
Synonyms:HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:Hydrolase
Mol. Mass.:33264.56
Organism:Homo sapiens (Human)
Description:Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50160280
n/a
NameBDBM50160280
Synonyms:CHEMBL3787340
TypeSmall organic molecule
Emp. Form.C25H25N5O5
Mol. Mass.475.4965
SMILESCOc1ccc(cc1)[C@@H]1[C@H](N(C2CCN(CC2)C(=O)n2cncn2)C1=O)c1ccc2OCOc2c1 |r|
Structure
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