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TargetPotassium voltage-gated channel subfamily A member 5
LigandBDBM50160699
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1566417 (CHEMBL3790037)
IC50 1500±n/a nM
Citation Kajanus, JJacobson, IÅstrand, AOlsson, RIGran, UBjöre, AFjellström, ODavidsson, ÖEmtenäs, HDahlén, ALöfberg, BYuan, ZQSundell, JCassel, JGyll, JIliefski, THögberg, ÅLindhardt, EMalmberg, J Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach. Bioorg Med Chem Lett26:2023-9 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Potassium voltage-gated channel subfamily A member 5
Name:Potassium voltage-gated channel subfamily A member 5
Synonyms:HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:Enzyme
Mol. Mass.:67222.47
Organism:Homo sapiens (Human)
Description:P22460
Residue:613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA
DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ
RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ
SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF
EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG
SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII
DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL
QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT
VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG
TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL
YALCLDTSRETDL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50160699
n/a
NameBDBM50160699
Synonyms:CHEMBL3786460
TypeSmall organic molecule
Emp. Form.C26H24F2N2O2
Mol. Mass.434.4778
SMILESCC(C)(C)NC(=O)C1N(Cc2ccccc2-c2ccc(F)c(F)c2)C(=O)c2ccccc12
Structure
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