Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProteasome subunit beta type-5
LigandBDBM50069989
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1567337 (CHEMBL3789477)
IC50 7.1±n/a nM
Citation Shi, JLei, MWu, WFeng, HWang, JChen, SZhu, YHu, SLiu, ZJiang, C Design, synthesis and docking studies of novel dipeptidyl boronic acid proteasome inhibitors constructed fromaa- andaß-amino acids. Bioorg Med Chem Lett26:1958-62 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Proteasome subunit beta type-5
Name:Proteasome subunit beta type-5
Synonyms:20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:Protein
Mol. Mass.:28480.96
Organism:Homo sapiens (Human)
Description:n/a
Residue:263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50069989
n/a
NameBDBM50069989
Synonyms:(R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic acid | BORTEZOMIB | CHEMBL325041 | Dipeptidyl boronic acid derivative | LDP-341 | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | PS-341 | Peptidyl boronic acid derivative | US11542283, Compound Velcade | Velcade | cid_387447
TypeSmall organic molecule
Emp. Form.C19H25BN4O4
Mol. Mass.384.237
SMILESCC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: