Reaction Details |
| Report a problem with these data |
Target | Platelet-activating factor acetylhydrolase |
---|
Ligand | BDBM50162136 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1572480 (CHEMBL3796340) |
---|
IC50 | 1.7±n/a nM |
---|
Citation | Chen, X; Wang, K; Xu, W; Ma, Q; Chen, M; Du, L; Mo, M; Wang, Y; Shen, J Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors as a Potential Therapy for Diabetic Macular Edema. J Med Chem59:2674-87 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Platelet-activating factor acetylhydrolase |
---|
Name: | Platelet-activating factor acetylhydrolase |
Synonyms: | 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase |
Type: | PROTEIN |
Mol. Mass.: | 50084.41 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_156212 |
Residue: | 441 |
Sequence: | MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
|
|
|
BDBM50162136 |
---|
n/a |
---|
Name | BDBM50162136 |
Synonyms: | CHEMBL3792924 |
Type | Small organic molecule |
Emp. Form. | C23H19ClF5N3O5S |
Mol. Mass. | 579.924 |
SMILES | Cn1c(cc(OCc2cc(F)c(Oc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)nc1=O)N1CCS(=O)(=O)CC1 |
Structure |
|