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TargetProteasome subunit beta type-5
LigandBDBM50163693
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1572440 (CHEMBL3796231)
IC50 2.5±n/a nM
Citation Lei, MFeng, HWang, CLi, HShi, JWang, JLiu, ZChen, SHu, SZhu, Y 3D-QSAR-aided design, synthesis, in vitro and in vivo evaluation of dipeptidyl boronic acid proteasome inhibitors and mechanism studies. Bioorg Med Chem24:2576-88 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Proteasome subunit beta type-5
Name:Proteasome subunit beta type-5
Synonyms:20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:Protein
Mol. Mass.:28480.96
Organism:Homo sapiens (Human)
Description:n/a
Residue:263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
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  Blast E-value cutoff:
BDBM50163693
n/a
NameBDBM50163693
Synonyms:CHEMBL3793093
TypeSmall organic molecule
Emp. Form.C39H45BN2O4
Mol. Mass.616.597
SMILES[H][C@@]12C[C@@]([H])(C1(C)C)[C@]1(C)OB(OC1C2)[C@H](CC(C)C)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)c1ccc2ccccc2c1 |r|
Structure
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