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TargetSphingosine 1-phosphate receptor 1
LigandBDBM50164498
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1574131 (CHEMBL3801746)
EC50 0.540000±n/a nM
Citation Watterson, SHGuo, JSpergel, SHLangevine, CMMoquin, RVShen, DRYarde, MCvijic, MEBanas, DLiu, RSuchard, SJGillooly, KTaylor, TRex-Rabe, SShuster, DJMcIntyre, KWCornelius, GD'Arienzo, CMarino, ABalimane, PWarrack, BSalter-Cid, LMcKinnon, MBarrish, JCCarter, PHPitts, WJXie, JDyckman, AJ Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series. J Med Chem59:2820-40 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-phosphate receptor 1
Name:Sphingosine 1-phosphate receptor 1
Synonyms:CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:Enzyme
Mol. Mass.:42836.02
Organism:Homo sapiens (Human)
Description:P21453
Residue:382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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  Blast E-value cutoff:
BDBM50164498
n/a
NameBDBM50164498
Synonyms:CHEMBL3798735
TypeSmall organic molecule
Emp. Form.C24H20F2N4O4
Mol. Mass.466.4368
SMILESCC(F)(F)c1c(noc1-c1ccccc1)-c1nc(no1)-c1ccc(CN2CC(C2)C(O)=O)cc1
Structure
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