| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50164531 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1575026 (CHEMBL3803623) |
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| IC50 | 92±n/a nM |
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| Citation |  Heimburg, T; Chakrabarti, A; Lancelot, J; Marek, M; Melesina, J; Hauser, AT; Shaik, TB; Duclaud, S; Robaa, D; Erdmann, F; Schmidt, M; Romier, C; Pierce, RJ; Jung, M; Sippl, W Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis. J Med Chem59:2423-35 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HDAC8 | Histone deacetylase 8 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49771.73 |
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| Organism: | Schistosoma mansoni |
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| Description: | ChEMBL_116785 |
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| Residue: | 440 |
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| Sequence: | MSVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDSPSRMYEAVT
AFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDCPGFPSVFDYSLAAVQGSLA
AASALICRHCEVVINWGGGWHHAKRSEASGFCYLNDIVLAIHRLVSSTPPETSPNRQTRV
LYVDLDLHHGDGVEEAFWYSPRVVTFSVHHASPGFFPGTGTWNMVDNDKLPIFLNGAGRG
RFSAFNLPLEEGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNF
YPNLNLDSDCDSECSLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLWTRVTALTIEE
VKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPHESHNKTLDSIQKHHRRILEQLRNYAD
LNKLIYDYDQVYQLYNLTGM
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| BDBM50164531 |
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| n/a |
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| Name | BDBM50164531 |
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| Synonyms: | CHEMBL3799246 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20N2O4 |
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| Mol. Mass. | 376.4052 |
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| SMILES | CCOc1ccc(cc1NC(=O)c1ccc(cc1)-c1ccccc1)C(=O)NO |
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| Structure | 
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