| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50397360 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1575271 (CHEMBL3801582) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Heimburg, T; Chakrabarti, A; Lancelot, J; Marek, M; Melesina, J; Hauser, AT; Shaik, TB; Duclaud, S; Robaa, D; Erdmann, F; Schmidt, M; Romier, C; Pierce, RJ; Jung, M; Sippl, W Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis. J Med Chem59:2423-35 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50397360 |
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| n/a |
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| Name | BDBM50397360 |
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| Synonyms: | CHEMBL2170177 | US10188756, Compound CN110 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N2O3 |
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| Mol. Mass. | 296.3205 |
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| SMILES | COc1ccc(Cn2ccc3ccc(cc23)C(=O)NO)cc1 |
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| Structure | 
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