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TargetWD repeat-containing protein 5 (WDR5)
LigandBDBM50164787
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1575813
IC50 0.900000±n/a nM
Citation Getlik MSmil DZepeda-Velázquez CBolshan YPoda GWu HDong AKuznetsova EMarcellus RSenisterra GDombrovski LHajian TKiyota TSchapira MArrowsmith CHBrown PJVedadi MAl-Awar R Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J Med Chem 59:2478-96 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
WD repeat-containing protein 5 (WDR5)
Name:WD repeat-containing protein 5 (WDR5)
Synonyms:WD repeat-containing protein 5 | WD repeat-containing protein 5 (WRD5)
Type:Protein
Mol. Mass.:36597.13
Organism:Homo sapiens (Human)
Description:P61964
Residue:334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
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  Blast E-value cutoff:
BDBM50164787
n/a
NameBDBM50164787
Synonyms:CHEMBL3798088
TypeSmall organic molecule
Emp. Form.C29H46N8O5
Mol. Mass.586.7261
SMILESCC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@](C)(CCCCNC(=O)[C@H](NC1=O)c1ccccc1)NC(=O)C(C)C |r|
Structure
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