| Reaction Details |
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 | Report a problem with these data |
| Target | WD repeat-containing protein 5 |
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| Ligand | BDBM50164792 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1575810 (CHEMBL3801642) |
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| Kd | 40±n/a nM |
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| Citation |  Getlik, M; Smil, D; Zepeda-Velázquez, C; Bolshan, Y; Poda, G; Wu, H; Dong, A; Kuznetsova, E; Marcellus, R; Senisterra, G; Dombrovski, L; Hajian, T; Kiyota, T; Schapira, M; Arrowsmith, CH; Brown, PJ; Vedadi, M; Al-Awar, R Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J Med Chem59:2478-96 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| WD repeat-containing protein 5 |
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| Name: | WD repeat-containing protein 5 |
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| Synonyms: | BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 36597.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P61964 |
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| Residue: | 334 |
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| Sequence: | MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
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| BDBM50164792 |
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| n/a |
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| Name | BDBM50164792 |
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| Synonyms: | CHEMBL3798198 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25F3N4O3 |
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| Mol. Mass. | 498.4969 |
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| SMILES | CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccc2OCCc2c1 |
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| Structure | 
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