Reaction Details |
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Target | 5-hydroxytryptamine receptor 2A |
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Ligand | BDBM50165203 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1572988 (CHEMBL3801702) |
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Ki | 0.043000±n/a nM |
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Citation | Bielenica, A; Kedzierska, E; Kolinski, M; Kmiecik, S; Kolinski, A; Fiorino, F; Severino, B; Magli, E; Corvino, A; Rossi, I; Massarelli, P; Koziol, AE; Sawczenko, A; Struga, M 5-HT2 receptor affinity, docking studies and pharmacological evaluation of a series of 1,3-disubstituted thiourea derivatives. Eur J Med Chem116:173-186 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2A |
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Name: | 5-hydroxytryptamine receptor 2A |
Synonyms: | 5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52852.05 |
Organism: | Rattus norvegicus (rat) |
Description: | Rat cortex membranes 5-HT2A receptors. |
Residue: | 471 |
Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
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BDBM50165203 |
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n/a |
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Name | BDBM50165203 |
Synonyms: | CHEMBL3617113 |
Type | Small organic molecule |
Emp. Form. | C14H9ClF4N2S |
Mol. Mass. | 348.746 |
SMILES | Fc1ccc(NC(=S)Nc2cccc(c2)C(F)(F)F)cc1Cl |
Structure |
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