Ki Summary

Reaction Details

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Target

Cannabinoid receptor 2

Ligand

BDBM50165679

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1574215 (CHEMBL3802220)

811±n/a nM

Citation

Bertini, S; Chicca, A; Arena, C; Chicca, S; Saccomanni, G; Gertsch, J; Manera, C; Macchia, M Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands. Eur J Med Chem116:252-266 (2016) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cannabinoid receptor 2

Name:

Cannabinoid receptor 2

Synonyms:

CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

39690.94

Organism:

Homo sapiens (Human)

Description:

P34972

Residue:

360

Sequence:

MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC

BDBM50165679

n/a

Name

BDBM50165679

Synonyms:

CHEMBL3797983

Type

Small organic molecule

Emp. Form.

C29H32FNO3

Mol. Mass.

461.5677

SMILES

COc1ccc(cc1)-c1cc(Cc2ccc(F)cc2)c(OC)c(c1)C(=O)N[C@H]1CC[C@H](C)CC1 |r,wU:30.33,wD:27.29,(6.66,-5.09,;6.66,-3.86,;5.33,-3.08,;5.34,-1.54,;4,-.77,;2.67,-1.54,;2.67,-3.08,;4,-3.85,;1.33,-.77,;1.33,.77,;,1.54,;0,3.08,;1.34,3.85,;1.34,5.39,;2.68,6.15,;4.01,5.38,;5.08,5.99,;4.01,3.84,;2.67,3.07,;-1.33,.77,;-2.67,1.54,;-3.74,.92,;-1.33,-.77,;,-1.54,;-2.67,-1.54,;-3.73,-.93,;-2.66,-3.08,;-4,-3.86,;-5.33,-3.09,;-6.66,-3.86,;-6.66,-5.4,;-7.73,-6.01,;-5.33,-6.17,;-4,-5.4,)|

Structure