| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 5-hydroxylase 1 |
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| Ligand | BDBM50167397 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1574259 |
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| IC50 | 14±n/a nM |
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| Citation |  Goldberg, DR; De Lombaert, S; Aiello, R; Bourassa, P; Barucci, N; Zhang, Q; Paralkar, V; Stein, AJ; Valentine, J; Zavadoski, W Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett26:2855-2860 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 5-hydroxylase 1 |
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| Name: | Tryptophan 5-hydroxylase 1 |
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| Synonyms: | TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50990.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1361824 |
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| Residue: | 444 |
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| Sequence: | MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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| BDBM50167397 |
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| n/a |
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| Name | BDBM50167397 |
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| Synonyms: | CHEMBL3799918 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H32F3N5O4 |
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| Mol. Mass. | 583.6014 |
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| SMILES | N[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(Oc2cccc(c2)C(F)(F)F)cccc1N1CCCCC1)C(O)=O |r| |
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| Structure | 
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