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TargetTryptophan 5-hydroxylase 1
LigandBDBM50167428
Substrate/Competitorn/a
Meas. Tech.ChEBML_1574259
IC50 6.0±n/a nM
Citation Goldberg, DRDe Lombaert, SAiello, RBourassa, PBarucci, NZhang, QParalkar, VStein, AJValentine, JZavadoski, W Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett26:2855-2860 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tryptophan 5-hydroxylase 1
Name:Tryptophan 5-hydroxylase 1
Synonyms:TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:PROTEIN
Mol. Mass.:50990.64
Organism:Homo sapiens (Human)
Description:ChEMBL_1361824
Residue:444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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  Blast E-value cutoff:
BDBM50167428
n/a
NameBDBM50167428
Synonyms:CHEMBL3797264
TypeSmall organic molecule
Emp. Form.C30H35N5O5
Mol. Mass.545.6294
SMILESCOc1cccc(Oc2cccc(N3CCCCC3)c2CN\C(N)=N\C(=O)c2ccc(C[C@H](N)C(O)=O)cc2)c1 |r|
Structure
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