| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tryptophan 5-hydroxylase 1 |
|---|
| Ligand | BDBM50167821 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1574259 (CHEMBL3802442) |
|---|
| IC50 | 15±n/a nM |
|---|
| Citation |  Goldberg, DR; De Lombaert, S; Aiello, R; Bourassa, P; Barucci, N; Zhang, Q; Paralkar, V; Stein, AJ; Valentine, J; Zavadoski, W Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett26:2855-2860 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tryptophan 5-hydroxylase 1 |
|---|
| Name: | Tryptophan 5-hydroxylase 1 |
|---|
| Synonyms: | TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50990.64 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1361824 |
|---|
| Residue: | 444 |
|---|
| Sequence: | MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
|
|
|
|---|
| BDBM50167821 |
|---|
| n/a |
|---|
| Name | BDBM50167821 |
|---|
| Synonyms: | CHEMBL3797220 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H31N5O3 |
|---|
| Mol. Mass. | 437.5346 |
|---|
| SMILES | CC1CCCCN1c1ccccc1CN\C(N)=N\C(=O)c1ccc(C[C@H](N)C(O)=O)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
