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TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1
LigandBDBM50169051
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1577623 (CHEMBL3807231)
IC50 0.248000±n/a nM
Citation Abdel-Magid, AF MALT1 Inhibitors May Potentially Treat Lymphomas and Autoimmune Disorders. ACS Med Chem Lett7:205-6 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Name:Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms:MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase
Type:Enzyme
Mol. Mass.:92257.81
Organism:Homo sapiens (Human)
Description:Q9UDY8
Residue:824
Sequence:
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL
AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ
LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP
GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD
SKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLK
APLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENF
GNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDAL
KVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCH
LTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQI
QLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVS
KDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRG
LGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCS
RTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50169051
n/a
NameBDBM50169051
Synonyms:CHEMBL3805576 | US10442808, Example 27 | US9815842, Example 27
TypeSmall organic molecule
Emp. Form.C19H19ClF3N7O3S
Mol. Mass.517.912
SMILESCC(C)c1c(NC(=O)Nc2cnc(N3CCCS3(=O)=O)c(c2)C(F)(F)F)cnc2cc(Cl)nn12
Structure
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