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TargetSphingosine 1-phosphate receptor 1
LigandBDBM23163
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1578108 (CHEMBL3807063)
EC50 0.005000±n/a nM
Citation Dhar, TGXiao, HYXie, JLehman-McKeeman, LDWu, DRDabros, MYang, XTaylor, TLZhou, XDHeimrich, EMThomas, RMcIntyre, KWWarrack, BShi, HLevesque, PCZhu, JLHennan, JBalimane, PYang, ZMarino, AMCornelius, GD'Arienzo, CJMathur, AShen, DRCvijic, MESalter-Cid, LBarrish, JCCarter, PHDyckman, AJ Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials. ACS Med Chem Lett7:283-8 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-phosphate receptor 1
Name:Sphingosine 1-phosphate receptor 1
Synonyms:CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:Enzyme
Mol. Mass.:42836.02
Organism:Homo sapiens (Human)
Description:P21453
Residue:382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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  Blast E-value cutoff:
BDBM23163
n/a
NameBDBM23163
Synonyms:CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propoxy}phosphonic acid
TypeSmall organic molecule
Emp. Form.C19H34NO5P
Mol. Mass.387.4507
SMILESCCCCCCCCc1ccc(CCC(N)(CO)COP(O)(O)=O)cc1
Structure
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