| Reaction Details |
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 | Report a problem with these data |
| Target | Mycocyclosin synthase |
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| Ligand | BDBM31773 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1576820 (CHEMBL3806366) |
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| Kd | 73±n/a nM |
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| Citation |  Kavanagh, ME; Coyne, AG; McLean, KJ; James, GG; Levy, CW; Marino, LB; de Carvalho, LP; Chan, DS; Hudson, SA; Surade, S; Leys, D; Munro, AW; Abell, C Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J Med Chem59:3272-302 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mycocyclosin synthase |
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| Name: | Mycocyclosin synthase |
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| Synonyms: | CP121_MYCTU | Cytochrome P450 121 | Cytochrome P450 MT2 | cyp121 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43255.98 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_721243 |
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| Residue: | 396 |
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| Sequence: | MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF
SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL
LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI
NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS
FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR
KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE
ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW
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| BDBM31773 |
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| n/a |
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| Name | BDBM31773 |
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| Synonyms: | ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pevaryl | cid_68589 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15Cl3N2O |
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| Mol. Mass. | 381.684 |
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| SMILES | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 |
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| Structure | 
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