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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histamine H4 receptor | ||
| Ligand | BDBM50170161 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1577389 (CHEMBL3806523) | ||
| EC50 | 110±n/a nM | ||
| Citation |  Geyer, R; Nordemann, U; Strasser, A; Wittmann, HJ; Buschauer, A Conformational Restriction and Enantioseparation Increase Potency and Selectivity of Cyanoguanidine-Type Histamine H4 Receptor Agonists. J Med Chem59:3452-70 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histamine H4 receptor | |||
| Name: | Histamine H4 receptor | ||
| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 44517.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. | ||
| Residue: | 390 | ||
| Sequence: |
| ||
| BDBM50170161 | |||
| n/a | |||
| Name | BDBM50170161 | ||
| Synonyms: | CHEMBL3805392 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H24N6S | ||
| Mol. Mass. | 368.499 | ||
| SMILES | N#C\N=C(\NCCSc1ccccc1)N[C@H]1CC[C@H](CC1)c1c[nH]cn1 |r,wD:15.15,18.22,(-1.6,2.16,;-2.67,1.55,;-4,.78,;-4,-.77,;-5.34,-1.53,;-6.67,-.76,;-8.01,-1.53,;-9.34,-.76,;-10.68,-1.52,;-12.01,-.75,;-13.35,-1.52,;-13.35,-3.06,;-12.01,-3.83,;-10.68,-3.06,;-2.67,-1.54,;-1.33,-.77,;,-1.54,;1.33,-.77,;1.33,.77,;,1.54,;-1.33,.77,;2.67,1.54,;4.05,.9,;5.09,2.04,;4.32,3.38,;2.81,3.06,)| | ||
| Structure | 
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