| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H4 receptor |
|---|
| Ligand | BDBM50170118 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1577396 (CHEMBL3806530) |
|---|
| EC50 | 538±n/a nM |
|---|
| Citation |  Geyer, R; Nordemann, U; Strasser, A; Wittmann, HJ; Buschauer, A Conformational Restriction and Enantioseparation Increase Potency and Selectivity of Cyanoguanidine-Type Histamine H4 Receptor Agonists. J Med Chem59:3452-70 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H4 receptor |
|---|
| Name: | Histamine H4 receptor |
|---|
| Synonyms: | HH4R | HRH4_MOUSE | Hrh4 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 44272.75 |
|---|
| Organism: | Mus musculus (mouse) |
|---|
| Description: | Cell pellets from SK-N-MC cells transfected with mouse H4 receptor were used in binding assay. |
|---|
| Residue: | 391 |
|---|
| Sequence: | MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAIS
DFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAV
SYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTIT
MLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSN
PGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRG
RKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLY
PLCHRRFQKAFWKILCVTKQPALSQNQSVSS
|
|
|
|---|
| BDBM50170118 |
|---|
| n/a |
|---|
| Name | BDBM50170118 |
|---|
| Synonyms: | CHEMBL3804906 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H18N6 |
|---|
| Mol. Mass. | 246.3115 |
|---|
| SMILES | CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N/C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
