| Reaction Details |
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 | Report a problem with these data |
| Target | Testis-specific serine/threonine-protein kinase 1 |
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| Ligand | BDBM2579 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1577793 (CHEMBL3807900) |
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| IC50 | 0.330000±n/a nM |
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| Citation |  Zhan, W; Xu, L; Dong, X; Dong, J; Yi, X; Ma, X; Qiu, N; Li, J; Yang, B; Zhou, Y; Hu, Y Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors. Eur J Med Chem117:47-58 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Testis-specific serine/threonine-protein kinase 1 |
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| Name: | Testis-specific serine/threonine-protein kinase 1 |
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| Synonyms: | Serine/threonine-protein kinase 22A | Stk22a | Stk22a | TSK-1 | TSK1 | TSSK-1 | TSSK1_MOUSE | Testis-specific kinase 1 | Testis-specific serine/threonine-protein kinase 1 | Tssk1 | Tssk1b |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41594.08 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_116792 |
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| Residue: | 365 |
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| Sequence: | MDDAAVLKRRGYIMGINLGEGSYAKVKSAYSERLKFNVAVKIIDRKKAPSDFLEKFLPRE
IEILAMLNHRSIVKTYEIFETSDGKVYIVMELGVQGDLLEFIKTRGALQEDDARKKFHQL
SSAIKYCHDLDVVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDDSGRLILSKTFCGSAA
YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH
LTGECKDLIYRMLQPDVNRRLHIDEILNHCWVQPKARGLSSGAINKEGESSRATEPSWIP
EPGADKKSATKLEPREEARSEARSESKPQEDTLQVVRQSENVGLSSELNRDTEEGHPQQP
SETHT
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| BDBM2579 |
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| n/a |
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| Name | BDBM2579 |
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| Synonyms: | (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one | CHEMBL388978 | Staurosporin, 4 | Staurosporine | Staurosporine, 8 | US20240002365, Compound staurosporine | US9206188, Staurosporine | US9226923, Staurosporine |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26N4O3 |
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| Mol. Mass. | 466.531 |
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| SMILES | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| |
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| Structure | 
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