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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | RAC-alpha serine/threonine-protein kinase | ||
| Ligand | BDBM50170421 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1577690 (CHEMBL3807471) | ||
| IC50 | 850±n/a nM | ||
| Citation |  Zhan, W; Xu, L; Dong, X; Dong, J; Yi, X; Ma, X; Qiu, N; Li, J; Yang, B; Zhou, Y; Hu, Y Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors. Eur J Med Chem117:47-58 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| RAC-alpha serine/threonine-protein kinase | |||
| Name: | RAC-alpha serine/threonine-protein kinase | ||
| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55681.25 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P31749 | ||
| Residue: | 480 | ||
| Sequence: |
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| BDBM50170421 | |||
| n/a | |||
| Name | BDBM50170421 | ||
| Synonyms: | CHEMBL3805319 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H20Cl5N5O | ||
| Mol. Mass. | 535.681 | ||
| SMILES | Cn1ncc(Cl)c1-c1c(Cl)c(C(=O)NC2(CCNCC2)c2ccc(Cl)c(Cl)c2)n(C)c1Cl |(.16,9.88,;-1.04,9.6,;-2.21,10.59,;-3.53,9.79,;-3.16,8.29,;-3.96,7.35,;-1.64,8.19,;-.74,6.95,;-1.21,5.48,;-2.38,5.09,;.04,4.6,;.04,3.06,;1.1,2.44,;-1.3,2.29,;-1.33,.77,;,1.54,;1.33,.77,;1.33,-.77,;,-1.54,;-1.33,-.77,;-2.63,-.02,;-3.98,.71,;-5.3,-.09,;-5.26,-1.63,;-6.31,-2.27,;-3.91,-2.36,;-3.88,-3.6,;-2.59,-1.56,;1.28,5.49,;2.45,5.1,;.8,6.95,;1.53,7.95,)| | ||
| Structure | 
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