Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | RAC-alpha serine/threonine-protein kinase | ||
| Ligand | BDBM50170432 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1577690 (CHEMBL3807471) | ||
| IC50 | 390±n/a nM | ||
| Citation |  Zhan, W; Xu, L; Dong, X; Dong, J; Yi, X; Ma, X; Qiu, N; Li, J; Yang, B; Zhou, Y; Hu, Y Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors. Eur J Med Chem117:47-58 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| RAC-alpha serine/threonine-protein kinase | |||
| Name: | RAC-alpha serine/threonine-protein kinase | ||
| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55681.25 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P31749 | ||
| Residue: | 480 | ||
| Sequence: |
| ||
| BDBM50170432 | |||
| n/a | |||
| Name | BDBM50170432 | ||
| Synonyms: | CHEMBL3805691 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H19Cl2FN4O2 | ||
| Mol. Mass. | 437.295 | ||
| SMILES | Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)NC1(CCNCC1)c1ccc(F)cc1 |(.16,9.88,;-1.04,9.6,;-2.21,10.59,;-3.53,9.79,;-3.16,8.29,;-3.96,7.35,;-1.64,8.19,;-.74,6.95,;-1.21,5.48,;.04,4.6,;1.28,5.49,;.8,6.95,;1.53,7.95,;.04,3.06,;1.1,2.44,;-1.3,2.29,;-1.33,.77,;,1.54,;1.33,.77,;1.33,-.77,;,-1.54,;-1.33,-.77,;-2.63,-.02,;-2.59,-1.56,;-3.91,-2.36,;-5.26,-1.63,;-6.31,-2.27,;-5.3,-.09,;-3.98,.71,)| | ||
| Structure | 
| ||