Reaction Details |
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Target | Integrase |
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Ligand | BDBM50170908 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1578163 (CHEMBL3807245) |
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IC50 | 700±n/a nM |
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Citation | Billamboz, M; Suchaud, V; Bailly, F; Lion, C; Andréola, ML; Christ, F; Debyser, Z; Cotelle, P 2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4. Eur J Med Chem117:256-68 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Integrase |
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Name: | Integrase |
Synonyms: | pol |
Type: | PROTEIN |
Mol. Mass.: | 32203.43 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_106649 |
Residue: | 288 |
Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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BDBM50170908 |
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n/a |
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Name | BDBM50170908 |
Synonyms: | CHEMBL3805115 |
Type | Small organic molecule |
Emp. Form. | C16H18N2O4 |
Mol. Mass. | 302.3251 |
SMILES | ON1C(=O)C(C(=O)NC2CCCCC2)c2ccccc2C1=O |
Structure |
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