| Reaction Details |
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 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase |
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| Ligand | BDBM50172059 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1577193 (CHEMBL3807567) |
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| IC50 | 6800±n/a nM |
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| Citation |  Yang, YS; Yang, B; Zou, Y; Li, G; Zhu, HL Design, biological evaluation and 3D QSAR studies of novel dioxin-containing triaryl pyrazoline derivatives as potential B-Raf inhibitors. Bioorg Med Chem24:3052-3061 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAF proto-oncogene serine/threonine-protein kinase |
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| Name: | RAF proto-oncogene serine/threonine-protein kinase |
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| Synonyms: | Craf | Proto-oncogene c-RAF | RAF proto-oncogene serine/threonine-protein kinase | RAF1_MOUSE | Raf-1 | Raf1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 72947.25 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_116790 |
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| Residue: | 648 |
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| Sequence: | MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDSGVPAPPSFPMRRMRESVSRMPASSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLHVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYE
LMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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| BDBM50172059 |
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| n/a |
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| Name | BDBM50172059 |
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| Synonyms: | CHEMBL3805508 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H26N2O3 |
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| Mol. Mass. | 462.539 |
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| SMILES | C(Oc1cccc(c1)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1)c1ccccc1 |c:11| |
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| Structure | 
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