| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Death-associated protein kinase 3 |
|---|
| Ligand | BDBM50172243 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1579515 (CHEMBL3810713) |
|---|
| IC50 | 10.0±n/a nM |
|---|
| Citation |  Dowling, JE; Alimzhanov, M; Bao, L; Chuaqui, C; Denz, CR; Jenkins, E; Larsen, NA; Lyne, PD; Pontz, T; Ye, Q; Holdgate, GA; Snow, L; O'Connell, N; Ferguson, AD Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo. ACS Med Chem Lett7:300-5 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Death-associated protein kinase 3 |
|---|
| Name: | Death-associated protein kinase 3 |
|---|
| Synonyms: | DAP kinase 3 | DAP-like kinase | DAPK3 | DAPK3_HUMAN | ZIP-kinase | ZIPK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52537.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_586564 |
|---|
| Residue: | 454 |
|---|
| Sequence: | MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREE
IEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFL
KQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGT
PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEY
FSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRLKTT
RLKEYTIKSHSSLPPNNSYADFERFSKVLEEAAAAEEGLRELQRSRRLCHEDVEALAAIY
EEKEAWYREESDSLGQDLRRLRQELLKTEALKRQAQEEAKGALLGTSGLKRRFSRLENRY
EALAKQVASEMRFVQDLVRALEQEKLQGVECGLR
|
|
|
|---|
| BDBM50172243 |
|---|
| n/a |
|---|
| Name | BDBM50172243 |
|---|
| Synonyms: | CHEMBL3103192 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H25N9O |
|---|
| Mol. Mass. | 419.4829 |
|---|
| SMILES | CN(CCN)c1ccc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)cc1NC(C)=O |
|---|
| Structure | 
|
|---|
Search and Browse
