| Reaction Details |
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 | Report a problem with these data |
| Target | Homeodomain-interacting protein kinase 4 |
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| Ligand | BDBM50172243 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1579505 (CHEMBL3810703) |
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| IC50 | 40±n/a nM |
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| Citation |  Dowling, JE; Alimzhanov, M; Bao, L; Chuaqui, C; Denz, CR; Jenkins, E; Larsen, NA; Lyne, PD; Pontz, T; Ye, Q; Holdgate, GA; Snow, L; O'Connell, N; Ferguson, AD Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo. ACS Med Chem Lett7:300-5 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Homeodomain-interacting protein kinase 4 |
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| Name: | Homeodomain-interacting protein kinase 4 |
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| Synonyms: | HIPK4 | HIPK4_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69426.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_655821 |
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| Residue: | 616 |
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| Sequence: | MSTIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLH
CMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQV
LTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRF
YRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLH
AACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVA
SRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH
YYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYCLAEEKEAAGMGSVAGSSPFFREEKAP
GMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPLKAAITGHHVPDSGPEPILAFYSS
RLAGRHKARKPPAGSKSDSNFSNLIRLSQVSPEDDRPCRGSSWEEGEHLGASAEPLAILQ
RDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHG
PPRGATSFLQHVTGHH
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| BDBM50172243 |
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| n/a |
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| Name | BDBM50172243 |
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| Synonyms: | CHEMBL3103192 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25N9O |
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| Mol. Mass. | 419.4829 |
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| SMILES | CN(CCN)c1ccc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)cc1NC(C)=O |
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| Structure | 
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