| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kallikrein-1 |
|---|
| Ligand | BDBM50172757 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1578582 (CHEMBL3811623) |
|---|
| Ki | 36±n/a nM |
|---|
| Citation |  Glunz, PW; Mueller, L; Cheney, DL; Ladziata, V; Zou, Y; Wurtz, NR; Wei, A; Wong, PC; Wexler, RR; Priestley, ES Atropisomer Control in Macrocyclic Factor VIIa Inhibitors. J Med Chem59:4007-18 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kallikrein-1 |
|---|
| Name: | Kallikrein-1 |
|---|
| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28874.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06870 |
|---|
| Residue: | 262 |
|---|
| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
|
|
|
|---|
| BDBM50172757 |
|---|
| n/a |
|---|
| Name | BDBM50172757 |
|---|
| Synonyms: | CHEMBL3808801 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H31N5O3 |
|---|
| Mol. Mass. | 509.5988 |
|---|
| SMILES | CN1Cc2cccc(NC(=O)OCC(C)(C)c3ccc(cc3)[C@@H](Nc3ccc4c(N)nccc4c3)C1=O)c2 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
